ORTRD contains detailed information on human OR genes, associated TFs, regulatory signs, log2 Fold Changes (log2FC), and TF binding motifs. Interactions can be visualized as signed directed graphs that represent activation or repression relationships within Gene Regulatory Networks (GRNs). Users can query the database to retrieve and download specific data subsets for customized analyses.
By combining experimentally validated interactions with functional annotations, ORTRD provides a high-coverage resource for interpreting GRNs in human olfaction. It allows researchers to explore transcriptional regulation with confidence and supports studies in genomics, physiology, and sensory biology.
ORTRD is a comprehensive, user-friendly resource for studying transcriptional regulation of human olfactory receptors. It is publicly accessible at https://ortrd.iiita.ac.in/ and will be updated periodically to incorporate new validated data.
Keywords: Olfaction, transcription factor, gene regulatory network
Author(s):Nidhi Dubey, Prabhat Tripathi, Imlimaong Aier, Ankish Arya, Amaresh Kumar Sahoo and Pritish Kumar Varadwaj*
Current Bioinformatics, Published on: 06 May, 2026