Few interesting research works/Publications on AI, receptor structure and next-generation artificial olfaction, bioelectronic noses, AI prediction and receptor biology. 

Year	Publication	PMID / DOI	Why the paper matters
2025	Emter R, et al. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology.	PMID 41075782; DOI 10.1016/j.cub.2025.09.041	Engineers poorly expressed human ORs for improved cell-surface expression and sensitivity, helping overcome a major bottleneck in receptor–odorant mapping.
2025	Odoemelam CS, Steuber V, Schmuker M. Computational modelling of olfactory receptors. BBA General Subjects.	PMID 40441539; DOI 10.1016/j.bbagen.2025.130825	Comprehensive treatment of docking, MD, pharmacophores, virtual screening and ML for predicting OR structure and ligand interactions.
2025	Ihara Y, et al. Predicting human olfactory perception by odorant structure and receptor activation profile. Chemical Senses.	PMID 39888390; DOI 10.1093/chemse/bjaf002	Shows that combining molecular structure with OR activation profiles can help explain/predict similarities in human odor perception.
2025	Choi D, et al. Flexible bioelectronic nose based on olfactory receptor/hydrogel hybrid nanostructures for direct detection of odorants in gas and liquid phases. Lab on a Chip.	PMID 40445130; DOI 10.1039/D4LC00789A	Demonstrates an OR-based flexible biosensor capable of detecting odorants across gas and liquid environments.
2025	Wu F, et al. A bioelectronic nose with a flexible and implantable neural interface for odor detection and tobacco evaluation. Analyst.	PMID 41170920; DOI 10.1039/D5AN00867K	Uses neural recordings plus pattern recognition as a biologically integrated electronic nose, achieving odor discrimination at very low concentrations.
2025	Chiera F, et al. An overview on olfaction in the biological, analytical, computational, and machine learning fields. Archiv der Pharmazie.	PMID 39439128; DOI 10.1002/ardp.202400414	Particularly useful interdisciplinary review connecting odor chemistry, receptors, analytical techniques, computational modeling and ML.
2024	de March CA, et al. Engineered odorant receptors illuminate the basis of odour discrimination. Nature.	PMID 39478229; DOI 10.1038/s41586-024-08126-0	Uses engineered consensus ORs and cryo-EM structures to reveal molecular mechanisms by which odorants bind and activate ORs.
2024	Dennler N, et al. High-speed odor sensing using miniaturized electronic nose. Science Advances.	PMID 39504378; DOI 10.1126/sciadv.adp1764	Demonstrates millisecond-scale artificial odor sensing and temporal odor-plume decoding relevant to robotics and real-world machine olfaction.
2024	Electronic Noses: From Gas-Sensitive Components and Practical Applications to Data Processing.	PMID 39123852	Reviews sensing materials, sensor arrays, pattern recognition, drift correction and applications across food, health and environmental monitoring.
2024	Abideen ZU, et al. Emerging trends in metal oxide-based electronic noses for healthcare applications: a review. Nanoscale.	PMID 38680123; DOI 10.1039/D4NR00073K	Reviews nanostructured metal-oxide sensor arrays and their translation into disease-oriented e-nose systems.
2023	Lee BK, Mayhew EJ, Sanchez-Lengeling B, et al. A principal odor map unifies diverse tasks in olfactory perception. Science.	PMID 37651511; DOI 10.1126/science.ade4401	Landmark graph-neural-network work producing a learned molecular representation—the Principal Odor Map—that predicts human odor perception.
2023	Taisz I, et al. Generating parallel representations of position and identity in the olfactory system. Cell.	PMID 37236194; DOI 10.1016/j.cell.2023.04.038	Shows how olfactory circuits can encode both odor identity and spatial information in parallel.
2023	Wang B, et al. Development of an electronic nose to characterize water quality parameters and odor concentration of wastewater… Water Research.	PMID 36940564; DOI 10.1016/j.watres.2023.119878	Illustrates translation of sensor-array olfaction into quantitative environmental odor and water-quality monitoring.
2022	Kim C, et al. Artificial olfactory sensor technology that mimics the olfactory mechanism: a comprehensive review. Biomaterials Research.	PMID 35986395; DOI 10.1186/s40824-022-00287-1	Excellent review connecting biological olfaction with MOS, electrochemical, SAW, QCM, polymer and bio-inspired electronic-nose technologies.
2022	Yoshii T, et al. Development of an odorant sensor with a cell-free synthesized olfactory receptor and a graphene field-effect transistor.	PMID 35286654; DOI 10.1007/s44211-022-00073-y	Combines cell-free OR production with graphene FET transduction, an important direction for scalable receptor-based sensors.
2022	Choi R, et al. Olfactory dysfunction and COVID-19.	PMID 35505955; DOI 10.1016/j.otot.2022.04.010	Reviews SARS-CoV-2-related anosmia/parosmia while explaining peripheral olfactory organization and recovery mechanisms.
2022	Prasad P, et al. Electronic nose and wireless sensor network for environmental monitoring application in pulp and paper industry: a review.	PMID 36207610; DOI 10.1007/s10661-022-10479-w	Connects e-nose sensing with distributed wireless environmental-monitoring architectures.
2021	Ackels T, et al. Fast odour dynamics are encoded in the olfactory system and guide behaviour. Nature.	PMID 33953395; DOI 10.1038/s41586-021-03514-2	Demonstrates that mammalian olfaction exploits millisecond-scale temporal structure in turbulent odor plumes.
2020	Hayasaka T, et al. An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol. Microsystems & Nanoengineering.	PMID 34567662; DOI 10.1038/s41378-020-0161-3	Shows that ML can extract discriminative odor information even from a single graphene transistor rather than a conventional large sensor array.
2020	Whitcroft KL, Hummel T. Olfactory Dysfunction in COVID-19: Diagnosis and Management. JAMA.	PMID 32432682; DOI 10.1001/jama.2020.8391	Concise influential clinical framework for diagnosis and management of COVID-associated smell loss.
2020	Sedaghat AR, Gengler I, Speth MM. Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance.	PMID 32366160; DOI 10.1177/0194599820926464	Helped establish smell loss as an epidemiologically useful symptom of SARS-CoV-2 infection.
2020	Speth MM, et al. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19.	PMID 32423357; DOI 10.1177/0194599820929185	Characterized prevalence, timing and severity of smell dysfunction during early COVID-19.
2020	Chung TWH, et al. Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review.	PMID 32548209; DOI 10.1093/ofid/ofaa199	Combined objective smell testing, clinical evaluation and systematic review to characterize COVID-related OD.
2019	van Geffen WH, et al. The electronic nose: emerging biomarkers in lung cancer diagnostics. Breathe.	PMID 32280381; DOI 10.1183/20734735.0309-2019	Reviews breathprints/e-noses as non-invasive tools for lung-cancer detection and phenotyping.
2019	Behera B, et al. Electronic nose: a non-invasive technology for breath analysis of diabetes and lung cancer patients. Journal of Breath Research.	PMID 30620934; DOI 10.1088/1752-7163/aafc77	Demonstrates disease classification using breath VOC patterns and an electronic nose.
2019	Orzechowska S, et al. Electronic Nose: Recent Developments in Gas Sensing and Molecular Mechanisms of Graphene Detection and Other Materials.	PMID 31877901; DOI 10.3390/ma13010080	Useful review of graphene and other advanced materials for artificial olfactory sensing.
2019	Liu YJ, Zeng M, Meng QH. Electronic nose using a bio-inspired neural network modeled on mammalian olfactory system for Chinese liquor classification.	PMID 30831708; DOI 10.1063/1.5064540	Explicitly translates mammalian olfactory processing principles into a neural-network architecture for machine olfaction.
2018	Maßberg D, Hatt H. Human Olfactory Receptors: Novel Cellular Functions Outside of the Nose. Physiological Reviews.	PMID 29897292; DOI 10.1152/physrev.00013.2017	Major review establishing the importance of ectopic ORs in tissues including skin, lung, heart, gut and reproductive organs.
2018	Dewan A, et al. Single olfactory receptors set odor detection thresholds. Nature Communications.	PMID 30038239; DOI 10.1038/s41467-018-05129-0	Demonstrates that individual receptor types can determine behavioral sensitivity thresholds for specific odorants.